Tuberculosis

Ferroptosis-related gene SOCS1, a marker for tuberculosis diagnosis and treatment, involves in macrophage polarization and facilitates bone destruction in tuberculosis

Available online 28 October 2021, 102140

Tuberculosis
https://doi.org/10.1016/j.tube.2021.102140Get rights and content

Abstract

This study was aimed to reveal the role of ferroptosis in tuberculosis infection. To elucidate the ferroptosis-related DEGs, GEO datasets associated with tuberculosis infection were downloaded. The two external validation GEO datasets were exploited for subsequent verification of the ferroptosis-related DEGs. We further evaluated the correlation among the ferroptosis-related DEGs, therapeutic effects, and drug resistance. Finally, we tried to reveal the engagement of the ferroptosis-related DEGs in bone destruction during TB infection. The present study identified SOCS1 as the only ferroptosis-related DEGs. Compared to the non-TB patients, up-regulation of SOCS1 was evident in the TB patients. After receiving standard anti-TB treatment, significant down-regulation of SOCS1 confirmed its acceptance as the marker for therapeutic efficacy. The involvement of SOCS1 has also been suggested in the regulation of the micro immune environment in TB. Furthermore, SOCS1 might play an important role in causing bone destruction during TB infection. FRGs-SOCS1 may be the key gene involved in the pathogenesis and progression of TB infection.

Keywords

TB

Macrophage polarization

Biomarkers

Bone destruction

Ferroptosis

Abbreviations

GSEA

Gene Set Enrichment Analysis

KEGG

Kyoto Encyclopedia of Genes and Genomes

DEGs

differentially expressed genes

EPTB

extrapulmonary tuberculosis

PTB

pulmonary tuberculosis

XDR-TB

extensively drug resistant tuberculosis

Non-MDR

multiple drug resistant

SOCS1

Suppressor of Cytokine Signaling 1

DS-TB

drug sensitive tuberculosis

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© 2021 Published by Elsevier Ltd.

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